UK 370106
Tocris Bioscience, part of Bio-Techne | Catalog # 2900
Highly selective MMP-3 and MMP-12 inhibitor
Key Product Details
Description
Highly selective MMP-3 and MMP-12 inhibitor
Product Description
UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers.Product Specifications
Molecular Weight
572.73
Formula
C35H44N2O5
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1-phenylethyl]amino]carbonyl]-2,2-dimethylpropyl]amino]carbonyl]-2-methyl-[1,1'-biphenyl]-4-hexanoic acid
CAS Number
230961-21-4
PubChem ID
9808181
InChI Key
NSMABJUGSNPHMN-BHYWQNONSA-N
SMILES
CC(C=C(CCC[C@@H](C(N[C@@H]([C@@](C)(C)C)C(N[C@H](COC)C3=CC=CC=C3)=O)=O)CC(O)=O)C=C2)=C2C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.27 | 100 | |
| Ethanol | 14.32 | 25 |
Preparing Stock Solutions
for UK 370106
The following data is based on the product molecular weight 572.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.75 mL | 8.73 mL | 17.46 mL |
| 5 mM | 0.35 mL | 1.75 mL | 3.49 mL |
| 10 mM | 0.17 mL | 0.87 mL | 1.75 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Whitlock A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts.
- Matthews Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics
- Fray A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem. 2003 PMID: 12877590
Product Specific Notices for UK 370106
For research use only
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