UB 165 fumarate

Name: UB 165 fumarate
Brand: Tocris Bioscience
SKU: 1348

Tocris Bioscience, part of Bio-Techne | Catalog # 1348

COA / SDS

Subunit selective nAChR agonist

Discontinued Product

1348 has been discontinued. View all Additional Nicotinic Receptor Agonists products.

Key Product Details

Description:	Subunit selective nAChR agonist
Chemical Name:	2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-ene fumarate
Purity:	≥99% (HPLC)
Molecular Weight:	350.8

View Full Technical Details for UB 165 fumarate

Technical Data
Citations

Biological Activity for UB 165 fumarate

UB 165 fumarate is a subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. K_i values are 0.27, 20 (IC₅₀), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.

Licensing Information

Sold with the permission of the University of Bristol

Technical Data for UB 165 fumarate

M. Wt	350.8
Formula	C₁₃H₁₅ClN₂.C₄H₄O₄
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
PubChem ID	71297058
InChi Key	DZFRKSLRKAKJIB-WLHGVMLRSA-N
Smiles	[H]OC(=O)\C=C\C(=O)O[H].ClC1=CC=C(C=N1)C1=CCCC2CCC1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for UB 165 fumarate

References are publications that support the biological activity of the product.

Wright Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid. Bioorg.Med.Chem.Lett.
Cao Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]DA release. Neuropharmacology 2005 PMID: 15617729
Sharples UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of DA release from rat striatal synaptosomes. J.Neurosci. 2000 PMID: 10751429