Trovafloxacin mesylate is a fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca²⁺. Inhibits Panx-1 (IC₅₀ ~ 4μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

512.46

Formula

C₂₀H₁₅F₃N₄O₃.CH₃SO₃H

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate

CAS Number

147059-75-4

PubChem ID

62960

InChI Key

DYNZICQDCVYXFW-GIPYJWDTSA-N

SMILES

O=C2C1=CC(F)=C(N4C[C@@]([C@H]5N)([H])[C@@]5([H])C4)N=C1N(C3=C(F)C=C(F)C=C3)C=C2C(O)=O.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	25.62	50
	DMSO	51.25	100

Preparing Stock Solutions for Trovafloxacin mesylate

The following data is based on the product molecular weight 512.46

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.76 mL	19.51 mL
5 mM	0.39 mL	1.95 mL	3.90 mL
10 mM	0.20 mL	0.98 mL	1.95 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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Background References

References are publications that support the biological activity of the product.

Gootz Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob.Agents Chemother. 1996 PMID: 9124824
Poon Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature 2014 PMID: 24646995
Neu and Chin In vitro activity of the new fluoroquinolone CP-99,219. Antimicrob.Agents Chemother. 1994 PMID: 7872757

Trovafloxacin mesylate

Tocris Bioscience, part of Bio-Techne | Catalog # 3863

Key Product Details

Description

Alternative Names

View all Antibiotics »

Product Description