Trovafloxacin mesylate

Name: Trovafloxacin mesylate
Brand: Tocris Bioscience
SKU: 3863
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3863

(1)

Citations (2)

COA / SDS

Antibiotic; inhibits bacterial DNA synthesis

Key Product Details

Description:	Antibiotic; inhibits bacterial DNA synthesis
Alternative Names:	CP 99219
Chemical Name:	7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate
Purity:	≥98% (HPLC)
Molecular Weight:	512.46

View Full Technical Details for Trovafloxacin mesylate

Technical Data
Citations / Reviews (1)

Biological Activity for Trovafloxacin mesylate

Trovafloxacin mesylate is a fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca²⁺. Inhibits Panx-1 (IC₅₀ ~ 4μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Trovafloxacin mesylate

Trovafloxacin mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Trovafloxacin mesylate

M. Wt	512.46
Formula	C₂₀H₁₅F₃N₄O₃.CH₃SO₃H
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	147059-75-4
PubChem ID	62960
InChi Key	DYNZICQDCVYXFW-GIPYJWDTSA-N
Smiles	O=C2C1=CC(F)=C(N4C[C@@]([C@H]5N)([H])[C@@]5([H])C4)N=C1N(C3=C(F)C=C(F)C=C3)C=C2C(O)=O.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Trovafloxacin mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	25.62	50
	DMSO	51.25	100

Preparing Stock Solutions for Trovafloxacin mesylate

The following data is based on the product molecular weight 512.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.76 mL	19.51 mL
5 mM	0.39 mL	1.95 mL	3.90 mL
10 mM	0.20 mL	0.98 mL	1.95 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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References for Trovafloxacin mesylate

References are publications that support the biological activity of the product.

Gootz Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob.Agents Chemother. 1996 PMID: 9124824
Poon Unexpected link between an antibiotic, pannexin channels and apoptosis. Nature 2014 PMID: 24646995
Neu and Chin In vitro activity of the new fluoroquinolone CP-99,219. Antimicrob.Agents Chemother. 1994 PMID: 7872757