Tropisetron hydrochloride

Name: Tropisetron hydrochloride
Brand: Tocris Bioscience
SKU: 2459

Tocris Bioscience, part of Bio-Techne | Catalog # 2459

Citations (10)

COA / SDS

Potent 5-HT3 antagonist; also α7 nAChR partial agonist

Key Product Details

Description:	Potent 5-HT₃ antagonist; also α7 nAChR partial agonist
Alternative Names:	Novaban,ICS 205930
Chemical Name:	(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	320.82

View Full Technical Details for Tropisetron hydrochloride

Technical Data
Citations

Biological Activity for Tropisetron hydrochloride

Tropisetron hydrochloride is a potent, orally active 5-HT₃ receptor antagonist. Antiemetic. Also partial agonist of α7 nAChR. Activates α7^Q79G-GlyR chimeric ion channels (EC₅₀ = 38 nM)

Technical Data for Tropisetron hydrochloride

M. Wt	320.82
Formula	C₁₇H₂₀N₂O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	105826-92-4
PubChem ID	656664
InChi Key	XIEGSJAEZIGKSA-KOQCZNHOSA-N
Smiles	O=C(O[C@@H]3C[C@@H]4CC[C@@H](N4C)C3)C2=CNC1=CC=CC=C12.O=C(O[C@@H]7C[C@H]8CC[C@H](N8C)C7)C6=CNC5=CC=CC=C56.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tropisetron hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	32.08	100
	DMSO	16.04	50

Preparing Stock Solutions for Tropisetron hydrochloride

The following data is based on the product molecular weight 320.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.59 mL	31.17 mL
5 mM	0.62 mL	3.12 mL	6.23 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for Tropisetron hydrochloride

References are publications that support the biological activity of the product.

Papke Activity of α7-selective agonists at nicotinic and serotonin 5HT₃ receptors expressed in Xenopus oocytes. Bioorg.Med.Chem.Lett. 2004 PMID: 15050614
Middlemiss and Tricklebank Centrally active 5-HT receptor agonists and antagonists. Neurosci.Biobehav.Rev. 1992 PMID: 1553108
Mhatre 5-HT₃ antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake. Eur.J.Pharmacol. 2004 PMID: 15140631
Seynaeve 5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granis. and tropisetron. Anticancer Drugs 1991 PMID: 1665723