tri-GalNAc-PEG3-Azide

Name: tri-GalNAc-PEG3-Azide
Brand: Tocris Bioscience
SKU: 8015

Tocris Bioscience, part of Bio-Techne | Catalog # 8015

COA / SDS

Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry

Key Product Details

Description:	Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
Purity:	≥90% (HPLC)
Molecular Weight:	1644.83

View Full Technical Details for tri-GalNAc-PEG3-Azide

Technical Data
Citations

Biological Activity for tri-GalNAc-PEG3-Azide

tri-GalNAc-PEG3-Azide is a functionalized asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development; each molecule incorporates three ASGPR ligands with a PEG3 linker and azide group reactive handle ready for conjugation. Upon binding to the ASGPR, tri-GalNAc conjugates are efficiently internalized via ASGPR-mediated endocytosis. tri-GalNAc conjugation can be employed as a strategy to effectively deliver cargo such as RNA or Cas9 complexes in a cell-specific manner to hepatocytes. Can be used to generate LYTACs, or labeled with dye for tissue imaging.

Technical Data for tri-GalNAc-PEG3-Azide

M. Wt	1644.83
Formula	C₇₀H₁₂₅N₁₃O₃₁
Storage	Store at -20°C
Purity	≥90% (HPLC)
CAS Number	2925590-71-0
InChi Key	QNGSUVMZQPQMPB-CNCRQLPOSA-N
Smiles	OC[C@H]([C@@H]([C@@H]([C@H]1NC(C)=O)O)O)O[C@H]1OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O)NC(CCOCCOCCOCCN=[N+]=[N-])=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for tri-GalNAc-PEG3-Azide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	5

Preparing Stock Solutions for tri-GalNAc-PEG3-Azide

The following data is based on the product molecular weight 1644.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.04 mM	15.20 mL	76.00 mL	151.99 mL
0.2 mM	3.04 mL	15.20 mL	30.40 mL
0.4 mM	1.52 mL	7.60 mL	15.20 mL
2 mM	0.30 mL	1.52 mL	3.04 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for tri-GalNAc-PEG3-Azide

References are publications that support the biological activity of the product.

Sanhueza Efficient liver targeting by polyvalent display of a compact ligand for the asialoglycoprotein receptor. J.Am.Chem.Soc. 2017 PMID: 28230359