Tolcapone

Name: Tolcapone
Brand: Tocris Bioscience
SKU: 5864

Tocris Bioscience, part of Bio-Techne | Catalog # 5864

Citations (2)

COA / SDS

COMT inhibitor; also inhibits transthyretin aggregation

Key Product Details

Description:	COMT inhibitor; also inhibits transthyretin aggregation
Alternative Names:	Tasmar,Ro 40-7592
Chemical Name:	(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Purity:	≥98% (HPLC)
Molecular Weight:	273.24

View Full Technical Details for Tolcapone

Technical Data
Citations

Biological Activity for Tolcapone

Tolcapone is a COMT inhibitor. Inhibits both brain and peripheral COMT. Also binds transthyretin (TTR) with high affinity (K_d1 and K_d2 values are 21 and 58 nM, respectively). Inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Orally bioavailable.

Technical Data for Tolcapone

M. Wt	273.24
Formula	C₁₄H₁₁NO₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	134308-13-7
PubChem ID	4659569
InChi Key	MIQPIUSUKVNLNT-UHFFFAOYSA-N
Smiles	OC1=C(O)C([N+]([O-])=O)=CC(C(C2=CC=C(C)C=C2)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tolcapone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	27.32	100
	DMSO	27.32	100

Preparing Stock Solutions for Tolcapone

The following data is based on the product molecular weight 273.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.66 mL	18.30 mL	36.60 mL
5 mM	0.73 mL	3.66 mL	7.32 mL
10 mM	0.37 mL	1.83 mL	3.66 mL
50 mM	0.07 mL	0.37 mL	0.73 mL

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References for Tolcapone

References are publications that support the biological activity of the product.

Männistö Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat. Br.J.Pharmacol. 1992 PMID: 1628144
Sant'Anna Repositioning tolc. as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity. Nat.Commun. 2016 PMID: 26902880