TMPyP4 tosylate
Tocris Bioscience, part of Bio-Techne | Catalog # 4253
Inhibitor of human telomerase
Product Description
TMPyP4 tosylate is a cationic porphyrin; inhibits human telomerase. Stacks with G tetrads to stabilize quadruplex DNA. Inhibits cell proliferation and induces cell death in three myeloma cell lines. Activity results in telomere shortening at concentrations between 1 and 5 μM.Product Specifications
Molecular Weight
1363.60
Formula
C72H66N8O12S4
Storage
Store at +4°C
Purity
≥95% (HPLC)
Chemical Name
5,10,15,20-Tetrakis(1-methylpyridinium-4-yl)porphyrin tetra(p-toluenesulfonate)
CAS Number
36951-72-1
PubChem ID
11979833
InChI Key
AKZFRMNXBLFDNN-UHFFFAOYSA-K
SMILES
CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.CC1=CC=C(C=C1)S([O-])(=O)=O.C[N+]1=CC=C(C=C1)C1=C2\C=CC(=N2)\C(=C2/N\C(\C=C2)=C(/C2=N/C(/C=C2)=C(\C2=CC=C\1N2)C1=CC=[N+](C)C=C1)C1=CC=[N+](C)C=C1)\C1=CC=[N+](C)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 68.18 | 50 |
Preparing Stock Solutions
for TMPyP4 tosylate
The following data is based on the product molecular weight 1363.60
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 1.47 mL | 7.33 mL | 14.67 mL |
| 2.5 mM | 0.29 mL | 1.47 mL | 2.93 mL |
| 5 mM | 0.15 mL | 0.73 mL | 1.47 mL |
| 25 mM | 0.03 mL | 0.15 mL | 0.29 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shi Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J.Med.Chem.
- Shammas Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol.Cancer Ther. 2003 PMID: 14555701
- Wheelhouse Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J.Am.Chem.Soc.
- Rha Effect of telomere and telomerase interactive agents on human tumor and normal cell lines. Clin.Cancer Res. 2000 PMID: 10741725
Product Specific Notices for TMPyP4 tosylate
For research use only
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