TM2 TEAD inhibitor

Name: TM2 TEAD inhibitor
Brand: Tocris Bioscience
SKU: 7917

Tocris Bioscience, part of Bio-Techne | Catalog # 7917

COA / SDS

Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling

Key Product Details

Description:	Potent and reversible inhibitor of TEAD mediated Hippo/Yap signalling
Chemical Name:	4-[3-(2-Cyclohexylethoxy)benzoyl]-N-phenyl-1-piperazinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	435.57

View Full Technical Details for TM2 TEAD inhibitor

Technical Data
Citations

Biological Activity for TM2 TEAD inhibitor

TM2 TEAD inhibitor is a potent and reversible TEA domain transcription factor inhibitor (IC₅₀ = 38 nM and 156 nM for TEAD4 auto-palmitoylation and TEAD2 palmitoylation, respectively). It inhibits TEAD-YAP association and transcriptional activity. TM2 TEAD inhibitor exhibits strong antiproliferation effects as a single agent or in combination with a MEK inhibitor in YAP-dependent cancer cells. Also inhibits YAP-dependent liver organoid growth ex vivo.

Technical Data for TM2 TEAD inhibitor

M. Wt	435.57
Formula	C₂₆H₃₃N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1008768-41-9
PubChem ID	68301145
InChi Key	LWLAYULJAJMPKG-UHFFFAOYSA-N
Smiles	O=C(N1CCN(CC1)C(C2=CC(OCCC3CCCCC3)=CC=C2)=O)NC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TM2 TEAD inhibitor

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.56	100
	ethanol	43.56	100

Preparing Stock Solutions for TM2 TEAD inhibitor

The following data is based on the product molecular weight 435.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.48 mL	22.96 mL
5 mM	0.46 mL	2.30 mL	4.59 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for TM2 TEAD inhibitor

References are publications that support the biological activity of the product.

Hu Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. eLife 2022 PMID: 36398861