TM 5441

Name: TM 5441
Brand: Tocris Bioscience
SKU: 6194

Tocris Bioscience, part of Bio-Techne | Catalog # 6194

Citations (11)

COA / SDS

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Key Product Details

Description:	Plasminogen activator inhibitor-1 (PAI-1) inhibitor
Chemical Name:	5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	450.8

View Full Technical Details for TM 5441

Technical Data
Citations

Biological Activity for TM 5441

TM 5441 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC₅₀ = 3.58 - 60.3 μM). Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and cardiac hypertrophy in mice. Renoprotective. Orally bioavailable.

Compound Libraries for TM 5441

TM 5441 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TM 5441

M. Wt	450.8
Formula	C₂₁H₁₆ClN₂NaO₆
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	2319722-53-5
PubChem ID	44250349
InChi Key	RDKPAESSEMYFJL-UHFFFAOYSA-M
Smiles	O=C(C1=C(C=CC(Cl)=C1)NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)O[Na]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TM 5441

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.08	100

Preparing Stock Solutions for TM 5441

The following data is based on the product molecular weight 450.8.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.09 mL	22.18 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for TM 5441

References are publications that support the biological activity of the product.

Eren PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc.Natl.Acad.Sci.USA. 2014 PMID: 24778222
Jeong Novel plasminogen activator inhibitor-1 inhibitors prevent diabetic kidney injury in a mouse model. PLoS One. 2016 PMID: 27258009
Boe Plasminogen activator inhibitor-1 antagonist TM5441 attenuates N^ω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence. Circulation. 2013 PMID: 24092817
Placencio Small molecule inhibitors of plasminogen activator inhibitor-1 elicit anti-tumorigenic and anti-angiogenic activity. PLoS One. 2015 PMID: 26207899