threo Ifenprodil hemitartrate
Tocris Bioscience, part of Bio-Techne | Catalog # 2892
GluN2B-selective NMDA antagonist; also σ agonist
Discontinued Product
2892 has been discontinued.
View all NMDA Receptor Antagonists products.
Key Product Details
Description
GluN2B-selective NMDA antagonist; also σ agonist
Product Description
threo Ifenprodil hemitartrate is a potent σ receptor agonist (Ki values are 59.1 and 2 nM for σ1 and σ2 receptors respectively) and GluN2B (formally NR2B) subunit-selective NMDA receptor antagonist (IC50 values are 0.22 and 324.8 μM at GluN2B and GluN2A respectively). Displays ~8-fold reduced affinity at α-adrenoceptors compared to Ifenprodil (Cat.No. 0545). Inhibits the hERG potassium channel (IC50 = 88 nM) and exhibits antiarrhythmic activity in vivo.Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Product Specifications
Molecular Weight
400.49
Formula
C21H27NO2.½C4H6O6
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(1S*,2S*)-threo-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemitartrate
PubChem ID
11957579
InChI Key
DMPRDSPPYMZQBT-UHFFFAOYSA-N
SMILES
OC(C=C3)=CC=C3[C@H](O)[C@H](C)N2CCC(CC2)CC1=CC=CC=C1.OC(C=C6)=CC=C6[C@H](O)[C@H](C)N5CCC(CC5)CC4=CC=CC=C4.OC(C=C9)=CC=C9[C@@H](O)[C@@H](C)N8CCC(CC8)CC7=CC=CC=C7.OC(C=C%12)=CC=C%12[C@@H](O)[C@@H](C)N%11CCC(CC%11)CC%10=CC=CC=C%10.O=C(O)C(O)C(O)C(O)=O.O=C(O)C(O)C(O)C(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 10.01 | 25 | |
| DMSO | 40.05 | 100 |
Preparing Stock Solutions
for threo Ifenprodil hemitartrate
The following data is based on the product molecular weight 400.49
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.48 mL | 24.97 mL |
| 5 mM | 0.50 mL | 2.50 mL | 4.99 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Avenet Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes. Eur.J.Pharmacol. 1996 PMID: 8838458
- Monassier σ2-receptor ligand-mediated inhibition of inwardly rectifying K+channels in the heart. J.Pharmacol.Exp.Ther. 2007 PMID: 17460149
- Hashimoto and London Interactions of erythro-ifenprodil, threo-ifenprodil and erythro-iodoifenprodil, and eliprodil with subtypes of σ receptors. Eur.J.Pharmacol. 1995 PMID: 7737340
Product Specific Notices for threo Ifenprodil hemitartrate
For research use only
Loading...
Loading...