Thioridazine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3070
Dopamine receptor antagonist; antipsychotic
Key Product Details
Description
Dopamine receptor antagonist; antipsychotic
Product Description
Thioridazine hydrochloride is a dopamine receptor antagonist that displays antipsychotic activity. Exhibits anticancer activity in cervical, endometrial and breast cancer cells; triggers apoptosis by targeting the PI 3-K/Akt/mTOR/p70 S6K pathway. Induces G1 cell cycle arrest. Selective inducer of cancer stem cell (CSC) differentiation.Product Specifications
Molecular Weight
407.04
Formula
C21H26N2S2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine hydrochloride
CAS Number
130-61-0
PubChem ID
66062
InChI Key
NZFNXWQNBYZDAQ-UHFFFAOYSA-N
SMILES
CN(CCCC4)C4CCN2C3=C(C=CC(SC)=C3)SC1=CC=CC=C12.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.53 | 75 | |
| DMSO | 40.7 | 100 |
Preparing Stock Solutions
for Thioridazine hydrochloride
The following data is based on the product molecular weight 407.04
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.46 mL | 12.28 mL | 24.57 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.91 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.46 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kang Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells. Apoptosis. 2012 PMID: 22460505
- Sachlos Identification of drugs including a DA receptor antagonist that selectively target cancer stem cells. Cell. 2012 PMID: 22632761
Product Specific Notices for Thioridazine hydrochloride
For research use only
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