Thioperamide

Tocris Bioscience, part of Bio-Techne | Catalog # 0644

H3 antagonist; also H4 inverse agonist
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Key Product Details

Description

H3 antagonist; also H4 inverse agonist

View all Histamine H3 Receptor Antagonists »

Product Description

Thioperamide is a potent histamine H3 and H4 antagonist/inverse agonist. Ki values are 25 and 27 nM for human recombinant H3 and H4 receptors respectively. Blocks eosinophil shape change (IC50 = 1.4 μM) and chemotaxis (IC50 = 519 nM) induced by histamine. Freely crosses the blood-brain barrier.

Product Specifications

Molecular Weight

292.44

Formula

C15H24N4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide

CAS Number

106243-16-7

PubChem ID

3035905

InChI Key

QKDDJDBFONZGBW-UHFFFAOYSA-N

SMILES

S=C(NC3CCCCC3)N(CC2)CCC2C1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.24 100
Ethanol 29.24 100

Preparing Stock Solutions for Thioperamide

The following data is based on the product molecular weight 292.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.10 mL 34.20 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Calculators

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Product Documents for Thioperamide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Thioperamide

For research use only

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