TH 9619 disodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 7719
MTHFD2 inhibitor
Product Description
TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC50 = 47 nM). It shows efficacity on HL-60 cell viability with EC50 of 11nM. In vitro, It shows antiproliferative efficacy in acute myeloid leukemia (AML) cells and T-ALL Jurkat cells. In vivo, TH9619 disodium salt impairs cancer progression in a mouse disease model of AML.Licensing Information
Sold under license from Thomas Helleday's Foundation for Medical Research and One-Carbon TherapeuticsProduct Specifications
Molecular Weight
495.33
Formula
C17H16FN7Na2O7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
Disodium N-[[5-[[2-(2,4-Diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)acetyl]amino]-3-fluoro-2-pyridinyl]carbonyl]-L-glutamate
InChI Key
AKIUEXPYEGJOLL-WWPIYYJJSA-L
SMILES
NC1=NC(C(CC(NC2=CN=C(C(F)=C2)C(N[C@H](C(O[Na])=O)CCC(O[Na])=O)=O)=O)=C(N1)N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 9.91 | 20 with gentle warming |
Preparing Stock Solutions
for TH 9619 disodium salt
The following data is based on the product molecular weight 495.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.09 mL | 50.47 mL | 100.94 mL |
| 1 mM | 2.02 mL | 10.09 mL | 20.19 mL |
| 2 mM | 1.01 mL | 5.05 mL | 10.09 mL |
| 10 mM | 0.20 mL | 1.01 mL | 2.02 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bonagas Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat.Cancer 2022 PMID: 35228749
Product Specific Notices for TH 9619 disodium salt
For research use only
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