TH 1760

Name: TH 1760
Brand: Tocris Bioscience
SKU: 7422

Tocris Bioscience, part of Bio-Techne | Catalog # 7422

COA / SDS

Potent and selective NUDT15 hydrolase inhibitor

Key Product Details

Description:	Potent and selective NUDT15 hydrolase inhibitor
Chemical Name:	6-[[4-(1H-Indol-5-ylcarbonyl)-1-piperazinyl]sulfonyl]-2(3H)-benzoxazolone
Purity:	≥95% (HPLC)
Molecular Weight:	426.45

View Full Technical Details for TH 1760

Technical Data
Citations

Biological Activity for TH 1760

TH 1760 is a potent and selective NUDT15 (nudix hydrolase 15) inhibitor (IC₅₀ = 29 nM). Displays selectivity for NUDT15 when assayed at 100 μM against other Nudix enzymes (MTH1, NUDT2, 5, 9, 12, 14, 18, 22) and pyrophosphatases or at 10 μM when assayed with a Eurofins Cerep Safety Screen44 panel. In vitro, TH 1760 treatment sensitizes cancer cell lines (NB4 and HL-60) to thiopurine.

Technical Data for TH 1760

M. Wt	426.45
Formula	C₂₀H₁₈N₄O₅S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2567914-01-4
PubChem ID	146048072
InChi Key	HNCVDRFFJZJQRW-UHFFFAOYSA-N
Smiles	O=C(C1=CC=C2NC=CC2=C1)N3CCN(S(=O)(C4=CC=C5NC(OC5=C4)=O)=O)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TH 1760

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.2	with gentle warming

Preparing Stock Solutions for TH 1760

The following data is based on the product molecular weight 426.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.45 mL	117.25 mL	234.49 mL
0.5 mM	4.69 mL	23.45 mL	46.90 mL
1 mM	2.34 mL	11.72 mL	23.45 mL
5 mM	0.47 mL	2.34 mL	4.69 mL

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References for TH 1760

References are publications that support the biological activity of the product.

Zhang Development of a chemical probe against NUDT15. Nat.Chem.Biol. 2020 PMID: 32690945