TFC 007
Tocris Bioscience, part of Bio-Techne | Catalog # 5108
Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
Key Product Details
Description
Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor
Product Description
TFC 007 is a potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50 = 83 nM). Inhibits PGD2 production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4 synthase, TXA2 synthase and microsomal prostaglandin E2 synthase.Product Specifications
Molecular Weight
487.55
Formula
C27H29N5O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[4-(4-Morpholinylcarbonyl)-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
CAS Number
927878-49-7
PubChem ID
16040067
InChI Key
NLSSUSRERAMBTA-UHFFFAOYSA-N
SMILES
O=C(C2CCN(C3=CC=C(NC(C4=CN=C(OC5=CC=CC=C5)N=C4)=O)C=C3)CC2)N1CCOCC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.76 | 100 |
Preparing Stock Solutions
for TFC 007
The following data is based on the product molecular weight 487.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.26 mL | 20.51 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.10 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Nabe Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs. Prostaglandins Other Lipid Mediat. 2011 PMID: 21601002
Product Specific Notices for TFC 007
For research use only
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