Terazosin hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1506
α1 antagonist; PGK1 activator
Key Product Details
Description
α1 antagonist; PGK1 activator
Product Description
Terazosin hydrochloride is a selective α1 antagonist. Increases phosphoglycerate kinase 1 (PGK1) activity (Kd = 2.9 μM). Upregulates glucose metabolism and increases ATP production. In an in vitro model of GI disease, terazosin reduces inflammation and protects against oxidative damage. Neuroprotective in in vivo models of ALS and Parkinson's Disease. Antihypertensive following oral or intravenous administration in vivo.Product Specifications
Molecular Weight
423.90
Formula
C19H25N5O4.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride
CAS Number
63074-08-8
PubChem ID
44383
InChI Key
IWSWDOUXSCRCKW-UHFFFAOYSA-N
SMILES
Cl.COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.48 | 20 with gentle warming |
Preparing Stock Solutions
for Terazosin hydrochloride
The following data is based on the product molecular weight 423.90
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.80 mL | 58.98 mL | 117.95 mL |
| 1 mM | 2.36 mL | 11.80 mL | 23.59 mL |
| 2 mM | 1.18 mL | 5.90 mL | 11.80 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hancock Actions of tera. and its enantiomers at subtypes of α1- and α2-adrenoceptors in vitro. J.Recept.Signal Transduct.Res. 1995 PMID: 8673721
- Maruyama Comparison of displacemental potencies of tera. enantiomers for α1-adrenoceptor subtypes. Biol.Pharm.Bull. 1994 PMID: 7820122
- Kyncl Pharmacology of tera. Am.J.Med. 1986 PMID: 2872801
Product Specific Notices for Terazosin hydrochloride
For research use only
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