Tenidap
Tocris Bioscience, part of Bio-Techne | Catalog # 2580
NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3
Discontinued Product
2580 has been discontinued.
View all Cyclooxygenase Inhibitors products.
Key Product Details
Description
NSAID, cyclooxygenase (COX-1) inhibitor. Also opener of KIR2.3
Alternative Names
CP 66248
Product Description
Tenidap is a NSAID that preferentially inhibits COX-1 (IC50 values are < 0.03, 1.2 and > 30 μM for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hKir2.3 channel (EC50 = 402 nM).Product Specifications
Molecular Weight
320.75
Formula
C14H9N2O3SCl
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
(Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide
CAS Number
120210-48-2
PubChem ID
54683953
InChI Key
LXIKEPCNDFVJKC-QXMHVHEDSA-N
SMILES
O=C1N(C(N)=O)C2=CC=C(Cl)C=C2/C1=C(O)\C3=CC=CS3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.07 | 100 |
Preparing Stock Solutions
for Tenidap
The following data is based on the product molecular weight 320.75
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.59 mL | 31.18 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kirchner Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J.Pharmacol.Exp.Ther. 1997 PMID: 9262379
- Liu Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3. Eur.J.Pharmacol. 2002 PMID: 11821021
- Moilanen CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro. Eicosanoids 1988 PMID: 2856170
Product Specific Notices for Tenidap
For research use only
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