TCS PrP Inhibitor 13

Name: TCS PrP Inhibitor 13
Brand: Tocris Bioscience
SKU: 3238

Tocris Bioscience, part of Bio-Techne | Catalog # 3238

Citations (28)

COA / SDS

Antiprion agent; inhibits PrPSc accumulation

Discontinued Product

3238 has been discontinued. View all Neuronal Metabolism Peptides and Compounds products.

Key Product Details

Description:	Antiprion agent; inhibits PrP^Sc accumulation
Chemical Name:	2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one
Purity:	≥98% (HPLC)
Molecular Weight:	281.27

View Full Technical Details for TCS PrP Inhibitor 13

Technical Data
Citations

Biological Activity for TCS PrP Inhibitor 13

TCS PrP Inhibitor 13 is an antiprion agent. Potently inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC₅₀ = 3 nM). Also reduces PrP expression and decreases proliferation and survival in schwannoma cell lines.

Technical Data for TCS PrP Inhibitor 13

M. Wt	281.27
Formula	C₁₅H₁₁N₃O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	34320-83-7
PubChem ID	2750328
InChi Key	FDAVFKZPGQEGDX-UHFFFAOYSA-N
Smiles	O=C(C2)N(C3=CC=CC=C3)N=C2C1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TCS PrP Inhibitor 13

References are publications that support the biological activity of the product.

Provenzano Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017 PMID: 28692055
Kimata New series of antiprion compounds: pyrazolone derivatives have potent activity of inhibiting protease-resistant prion protein accumulation. J.Med.Chem. 2007 PMID: 17850126

TCS PrP Inhibitor 13

Tocris Bioscience, part of Bio-Techne | Catalog # 3238

Key Product Details

Biological Activity for TCS PrP Inhibitor 13

Technical Data for TCS PrP Inhibitor 13

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TCS PrP Inhibitor 13

Product Documents for TCS PrP Inhibitor 13

COA

Certificate of Analysis

SDS

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