TCS JNK 6o
Tocris Bioscience, part of Bio-Techne | Catalog # 3222
Selective JNK inhibitor
Product Description
TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro.TCS JNK 6o synthesized to Ancillary Material Grade also available.
Product Specifications
Molecular Weight
356.38
Formula
C18H20N4O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide
CAS Number
894804-07-0
PubChem ID
11624601
InChI Key
KQMPRSZTUSSXND-UHFFFAOYSA-N
SMILES
CCOC1=NC(NC(=O)CC2=CC(OC)=CC=C2OC)=CC(N)=C1C#N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.64 | 100 |
Preparing Stock Solutions
for TCS JNK 6o
The following data is based on the product molecular weight 356.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.81 mL | 14.03 mL | 28.06 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.61 mL |
| 10 mM | 0.28 mL | 1.40 mL | 2.81 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kauskot Involvement of the mirogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. J.Biol.Chem. 2007 PMID: 17785464
- Szczepankiewicz Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med.Chem. 2006 PMID: 16759099
Product Specific Notices for TCS JNK 6o
For research use only
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