TCS 359

Tocris Bioscience, part of Bio-Techne | Catalog # 2591

COA / SDS

Potent FLT3 inhibitor

Key Product Details

Description:	Potent FLT3 inhibitor
Chemical Name:	2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	360.43

View Full Technical Details for TCS 359

Technical Data
Citations

Biological Activity for TCS 359

TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC₅₀ = 42 nM) that displays selectivity over a range of other kinases. Exhibits antiproliferative effects on MV4-11 cells, a human acute myelogenous leukemia cell line expressing a constitutively active mutant FLT3 (IC₅₀ = 340 nM).

Technical Data for TCS 359

M. Wt	360.43
Formula	C₁₈H₂₀N₂O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	301305-73-7
PubChem ID	1048845
InChi Key	FSPQCTGGIANIJZ-UHFFFAOYSA-N
Smiles	COC1=CC=C(C=C1OC)C(=O)NC1=C(C(N)=O)C2=C(CCCC2)S1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCS 359

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.81	30

Preparing Stock Solutions for TCS 359

The following data is based on the product molecular weight 360.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.3 mM	9.25 mL	46.24 mL	92.48 mL
1.5 mM	1.85 mL	9.25 mL	18.50 mL
3 mM	0.92 mL	4.62 mL	9.25 mL
15 mM	0.18 mL	0.92 mL	1.85 mL

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Reconstitution Calculator

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References for TCS 359

References are publications that support the biological activity of the product.

Patch Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3. Bioorg.Med.Chem.Lett. 2006 PMID: 16580199