TCS 1102
Tocris Bioscience, part of Bio-Techne | Catalog # 3818
Potent, dual orexin receptor antagonist
Key Product Details
Description
Potent, dual orexin receptor antagonist
Product Description
TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). Inhibits ADL-orexin B-mediated locomotion following i.p. administration in vivo and blocks orexin-A (Cat.No.1455) mediated increases in feeding behaviour. Brain penetrant.Licensing Information
Manufactured and sold under license from Merck & Co., Inc. for use solely for preclinical research purposes (ie: not for administration to or other use in humans)Product Specifications
Molecular Weight
470.59
Formula
C27H26N4O2S
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide
CAS Number
916141-36-1
PubChem ID
11960895
InChI Key
YSBGRVXJEMSEQY-DEOSSOPVSA-N
SMILES
O=C(CSC2=NC(C=CC=C5)=C5N2C)N1CCC[C@H]1[C@](NC3=CC=CC=C3C4=CC=CC=C4)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.06 | 100 | |
| Ethanol | 47.06 | 100 |
Preparing Stock Solutions
for TCS 1102
The following data is based on the product molecular weight 470.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.62 mL | 21.25 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.25 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bergman Proline bis-amides as potent dual orexin receptor antagonists. Bioorg.Med.Chem.Letts
- Khoo The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking. PLoS One 2017 PMID: 28296947
- Winrow Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. Neuropharmacology 2010 PMID: 19596018
Product Specific Notices for TCS 1102
For research use only
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