TCN 201

Tocris Bioscience, part of Bio-Techne | Catalog # 4154

COA / SDS

GluN1/GluN2A-selective NMDA antagonist

Key Product Details

Description:	GluN1/GluN2A-selective NMDA antagonist
Chemical Name:	3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	461.89

View Full Technical Details for TCN 201

Technical Data
Citations

Biological Activity for TCN 201

TCN 201 is a NMDA receptor antagonist selective for GluN1/GluN2A (formally NR1/NR2A) over GluN1/GluN2B (formally NR1/NR2B) containing receptors (pIC₅₀ values are 6.8 and <4.3, respectively, in human recombinant GluN1/GluN2A (formally NR1/NR2A) and GluN1/GluN2B (formally NR1/NR2B) FLIPR/Ca²⁺ assays).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Compound Libraries for TCN 201

TCN 201 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TCN 201

M. Wt	461.89
Formula	C₂₁H₁₇ClFN₃O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	852918-02-6
PubChem ID	4787937
InChi Key	FYIBXBFDXNPBSF-UHFFFAOYSA-N
Smiles	ClC1=C(F)C=CC(S(NCC2=CC=C(C(NNC(C3=CC=CC=C3)=O)=O)C=C2)(=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TCN 201

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	46.19	100

Preparing Stock Solutions for TCN 201

The following data is based on the product molecular weight 461.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.17 mL	10.83 mL	21.65 mL
5 mM	0.43 mL	2.17 mL	4.33 mL
10 mM	0.22 mL	1.08 mL	2.17 mL
50 mM	0.04 mL	0.22 mL	0.43 mL

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Reconstitution Calculator

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References for TCN 201

References are publications that support the biological activity of the product.

Gipson Reinstatement of nicotine seeking is mediated by glutamatergic plasticity. Proc.Natl.Acad.Sci.U S A [Epub ahead of print] 2013 PMID: 23671067
Hansen Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. J.Neurosci. 2012 PMID: 22553026
Shin Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat. Br.J.Pharmacol. 2011 PMID: 22142193
Edman TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology 2012 PMID: 22579927
Bettini Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J.Pharm.Exp.Ther. 2010 PMID: 20810618