TC-S 7006

Name: TC-S 7006
Brand: Tocris Bioscience
SKU: 5240

Tocris Bioscience, part of Bio-Techne | Catalog # 5240

Citations (5)

COA / SDS

Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

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Technical Data
Citations

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

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Product Description

TC-S 7006 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC₅₀ = 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro. Also reduces cytolytic activity of human CD8⁺ cytotoxic T lymphocytes. Cell permeable.

Product Specifications

Molecular Weight

404.83

Formula

C₂₁H₁₄ClFN₆

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

CAS Number

871307-18-5

PubChem ID

9549300

InChI Key

NMEUKWOOQOHUNA-UHFFFAOYSA-N

SMILES

FC(C(Cl)=C4)=CC=C4NC1=C2C(C=NC(NCC3=CN=CC=C3)=C2)=NC=C1C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.48	100

Preparing Stock Solutions for TC-S 7006

The following data is based on the product molecular weight 404.83

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.35 mL	24.70 mL
5 mM	0.49 mL	2.47 mL	4.94 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Background References

References are publications that support the biological activity of the product.

Wang Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27^Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D₃. Cell Cycle 2010 PMID: 21084834
Gavrin Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg.Med.Chem.Lett. 2005 PMID: 16165349
Chowdhury Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions. PLoS ONE 2014 PMID: 24642963