TC-S 7004

Name: TC-S 7004
Brand: Tocris Bioscience
SKU: 5088

Tocris Bioscience, part of Bio-Techne | Catalog # 5088

Citations (3)

COA / SDS

Potent and selective DYRK1A/B inhibitor

Key Product Details

Description:	Potent and selective DYRK1A/B inhibitor
Chemical Name:	N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	498.32

View Full Technical Details for TC-S 7004

Technical Data
Citations

Biological Activity for TC-S 7004

TC-S 7004 is a potent and selective DYRK1A/B inhibitor (IC₅₀ values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G₀ under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells.

Compound Libraries for TC-S 7004

TC-S 7004 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for TC-S 7004

M. Wt	498.32
Formula	C₂₃H₁₇Cl₂N₅O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1386979-55-0
PubChem ID	57523919
InChi Key	CQKBSRPVZZLCJE-UHFFFAOYSA-N
Smiles	O=C(NC3=CC(C(NCC4=CC(Cl)=CC=C4)=O)=CC=C3Cl)C2=CC1=CN=C(OC)N=C1NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-S 7004

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	49.83	100

Preparing Stock Solutions for TC-S 7004

The following data is based on the product molecular weight 498.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.01 mL	10.03 mL	20.07 mL
5 mM	0.40 mL	2.01 mL	4.01 mL
10 mM	0.20 mL	1.00 mL	2.01 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for TC-S 7004

References are publications that support the biological activity of the product.

Anderson Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett. 2013 PMID: 24239188
Ewton Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Mol.Cancer Ther. 2011 PMID: 21878655