TC NTR1 17
Tocris Bioscience, part of Bio-Techne | Catalog # 5087
Selective NTS1 partial agonist
Key Product Details
Description
Selective NTS1 partial agonist
Alternative Names
ML 301 analog
Product Description
TC NTR1 17 is a non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35.Product Specifications
Molecular Weight
522.98
Formula
C27H27ClN4O5
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine
CAS Number
1146757-96-1
PubChem ID
44157038
InChI Key
ZQUSYVORYNBGLG-FQEVSTJZSA-N
SMILES
O=C(N[C@@H](CC(C)C)C(O)=O)C2=NN(C(C3=C(OC)C=CC=C3OC)=C2)C1=C(C=CC(Cl)=C4)C4=NC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.3 | 100 | |
| 1eq. NaOH | 26.15 | 50 |
Preparing Stock Solutions
for TC NTR1 17
The following data is based on the product molecular weight 522.98
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.56 mL | 19.12 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.82 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hershberger Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 2014 PMID: 24332089
Product Specific Notices for TC NTR1 17
For research use only
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