TC KHNS 11

Name: TC KHNS 11
Brand: Tocris Bioscience
SKU: 6079

Tocris Bioscience, part of Bio-Techne | Catalog # 6079

COA / SDS

Potent and selective PI 3-kinase δ inhibitor; orally bioavailable

Discontinued Product

6079 has been discontinued. View all PI 3-Kinase Inhibitors products.

Key Product Details

Description:	Potent and selective PI 3-kinase δ inhibitor; orally bioavailable
Chemical Name:	5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	492.53

View Full Technical Details for TC KHNS 11

Technical Data
Citations

Biological Activity for TC KHNS 11

TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor (biochemical IC₅₀ values are 9, 262, 1650 and 4630 nM for PI 3-Kδ, PI 3-Kα, PI 3-Kβ and PI 3-Kγ, respectively; cellular IC₅₀ values are 49, 3440 and 6530 nM for PI 3-Kδ, PI 3-Kα and PI 3-Kβ, respectively). Selective for PI 3-Kδ over a panel of lipid and protein kinases. Inhibits B-cell function. Exhibits moderate oral bioavailability in vivo.

Technical Data for TC KHNS 11

M. Wt	492.53
Formula	C₂₈H₂₄N₆O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1431540-99-6
PubChem ID	86732669
InChi Key	QYTXJLQBSYAMGR-UHFFFAOYSA-N
Smiles	O=C(N1CCN(C(C)=O)CC1)C2=CC=CC(C3=NC=NC(C=C4)=C3C=C4C(C=C5C#N)=CN=C5OC)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for TC KHNS 11

References are publications that support the biological activity of the product.

Hoegenauer Discovery and pharmacological characterization of novel quinazoline-based PI3K delta-selective inhibitors. ACS Med.Chem.Lett. 2016 PMID: 27563400

TC KHNS 11

Tocris Bioscience, part of Bio-Techne | Catalog # 6079

Key Product Details

Biological Activity for TC KHNS 11

Technical Data for TC KHNS 11

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for TC KHNS 11

Product Documents for TC KHNS 11

COA

Certificate of Analysis

SDS

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