TC KHNS 11
Tocris Bioscience, part of Bio-Techne | Catalog # 6079
Potent and selective PI 3-kinase δ inhibitor; orally bioavailable
Discontinued Product
6079 has been discontinued.
View all PI 3-Kinase Inhibitors products.
Key Product Details
Description
Potent and selective PI 3-kinase δ inhibitor; orally bioavailable
Product Description
TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor (biochemical IC50 values are 9, 262, 1650 and 4630 nM for PI 3-Kδ, PI 3-Kα, PI 3-Kβ and PI 3-Kγ, respectively; cellular IC50 values are 49, 3440 and 6530 nM for PI 3-Kδ, PI 3-Kα and PI 3-Kβ, respectively). Selective for PI 3-Kδ over a panel of lipid and protein kinases. Inhibits B-cell function. Exhibits moderate oral bioavailability in vivo.Product Specifications
Molecular Weight
492.53
Formula
C28H24N6O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile
CAS Number
1431540-99-6
PubChem ID
86732669
InChI Key
QYTXJLQBSYAMGR-UHFFFAOYSA-N
SMILES
O=C(N1CCN(C(C)=O)CC1)C2=CC=CC(C3=NC=NC(C=C4)=C3C=C4C(C=C5C#N)=CN=C5OC)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.25 | 100 |
Preparing Stock Solutions
for TC KHNS 11
The following data is based on the product molecular weight 492.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.03 mL | 10.15 mL | 20.30 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.06 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.03 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.41 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hoegenauer Discovery and pharmacological characterization of novel quinazoline-based PI3K delta-selective inhibitors. ACS Med.Chem.Lett. 2016 PMID: 27563400
Product Specific Notices for TC KHNS 11
For research use only
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