TC JL 37
Tocris Bioscience, part of Bio-Techne | Catalog # 6125
Potent TYK2 inhibitor
Product Description
TC JL 37 is a potent inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.Product Specifications
Molecular Weight
376.74
Formula
C17H11ClF2N4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide
CAS Number
1258294-34-6
PubChem ID
56934550
InChI Key
NKALKXMQBFLGQI-CMPLNLGQSA-N
SMILES
F[C@@H]1C[C@@H]1C(NC2=CC(NC(C3=C(C=C(C#N)C=C3F)Cl)=O)=CC=N2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.67 | 100 |
Preparing Stock Solutions
for TC JL 37
The following data is based on the product molecular weight 376.74
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.27 mL | 26.54 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.31 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Liang Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 2013 PMID: 23668484
Product Specific Notices for TC JL 37
For research use only
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