TC-G 24
Tocris Bioscience, part of Bio-Techne | Catalog # 4353
Potent and selective GSK-3β inhibitor
Product Description
TC-G 24 is a potent GSK-3β inhibitor (IC50 = 17 nM); displays selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). Increases liver glycogen reserves in rodents. Brain penetrant.Product Specifications
Molecular Weight
330.73
Formula
C15H11ClN4O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine
CAS Number
1257256-44-2
PubChem ID
49857866
InChI Key
JYCNWQGNEJYDQS-UHFFFAOYSA-N
SMILES
CC(C=C3)=C(Cl)C=C3NC1=NN=C(C2=CC=C([N+]([O-])=O)C=C2)O1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.31 | 10 with gentle warming |
Preparing Stock Solutions
for TC-G 24
The following data is based on the product molecular weight 330.73
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.24 mL | 151.18 mL | 302.36 mL |
| 0.5 mM | 6.05 mL | 30.24 mL | 60.47 mL |
| 1 mM | 3.02 mL | 15.12 mL | 30.24 mL |
| 5 mM | 0.60 mL | 3.02 mL | 6.05 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for TC-G 24
For research use only
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