TC-E 5002
Tocris Bioscience, part of Bio-Techne | Catalog # 5089
Selective KDM2/7 inhibitor
Key Product Details
Description
Selective KDM2/7 inhibitor
Product Description
TC-E 5002 is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). Inhibits growth of HeLa and KYSE-150 cancer cells in vitro.Product Specifications
Molecular Weight
285.38
Formula
C15H27NO4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine
CAS Number
1453071-47-0
PubChem ID
71735843
InChI Key
NEHSERYKENINRH-UHFFFAOYSA-N
SMILES
O=C(N(CCC(O)=O)O)CCCCCCCCC1CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.54 | 100 | |
| 1eq. NaOH | 28.54 | 100 |
Preparing Stock Solutions
for TC-E 5002
The following data is based on the product molecular weight 285.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.50 mL | 17.52 mL | 35.04 mL |
| 5 mM | 0.70 mL | 3.50 mL | 7.01 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.50 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.70 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Suzuki Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J.Med.Chem. 2013 PMID: 23964788
Product Specific Notices for TC-E 5002
For research use only
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