TC-E 5001

Tocris Bioscience, part of Bio-Techne | Catalog # 5049

Potent tankyrase inhibitor
Discontinued Product
5049 has been discontinued. View all Tankyrase Inhibitors products.

Key Product Details

Description

Potent tankyrase inhibitor

View all Tankyrase Inhibitors »

Product Description

TC-E 5001 is a dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 μM). Inhibits Wnt signaling and stabilizes Axin2 levels.

Product Specifications

Molecular Weight

409.46

Formula

C20H19N5O3S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole

CAS Number

865565-29-3

PubChem ID

16013184

InChI Key

LQZSHPITKSPDLC-UHFFFAOYSA-N

SMILES

CC1=NN=C(SCC3=NC(C4=CC=C(OC)C=C4)=NO3)N1C2=CC=C(OC)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.95 100

Preparing Stock Solutions for TC-E 5001

The following data is based on the product molecular weight 409.46

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TC-E 5001

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TC-E 5001

For research use only

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