TC-DAPK 6
Tocris Bioscience, part of Bio-Techne | Catalog # 4301
Potent and selective inhibitor of DAPK1
Key Product Details
Description
Potent and selective inhibitor of DAPK1
Product Description
TC-DAPK 6 is a potent and selective, ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) (IC50 values are 69 and 225 nM for DAPK1 and DAPK3 respectively, when assayed with 10 μM ATP). Displays selectivity for DAPK1 over a range of 48 other kinases, including Abl, AMPK, Chk1, Met and Src (IC50 > 10 μM).Product Specifications
Molecular Weight
276.29
Formula
C17H12N2O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(4Z)-2-[(E)-2-Phenylethenyl)-4-(3-pyridinylmethylene)-5(4H)-oxazolone
CAS Number
2439180-90-0
PubChem ID
2360773
InChI Key
GFGMISOSPOPSHN-NOCYUORASA-N
SMILES
O=C1OC(/C=C/C3=CC=CC=C3)=N\C1=C/C2=CC=CN=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.81 | 50 |
Preparing Stock Solutions
for TC-DAPK 6
The following data is based on the product molecular weight 276.29
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 7.24 mL | 36.19 mL | 72.39 mL |
| 2.5 mM | 1.45 mL | 7.24 mL | 14.48 mL |
| 5 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 25 mM | 0.14 mL | 0.72 mL | 1.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Okamoto Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J.Med.Chem. 2009 PMID: 19877644
Product Specific Notices for TC-DAPK 6
For research use only
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