TC-A 2317 hydrochloride

Name: TC-A 2317 hydrochloride
Brand: Tocris Bioscience
SKU: 4066

Tocris Bioscience, part of Bio-Techne | Catalog # 4066

Citations (2)

COA / SDS

Potent, selective Aurora kinase A inhibitor

Key Product Details

Description:	Potent, selective Aurora kinase A inhibitor
Chemical Name:	2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	392.93

View Full Technical Details for TC-A 2317 hydrochloride

Technical Data
Citations

Biological Activity for TC-A 2317 hydrochloride

TC-A 2317 hydrochloride is a potent Aurora kinase A inhibitor (K_i = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC₅₀ values > 1000 nM). Exhibits good cell permeability and antitumor activity.

Technical Data for TC-A 2317 hydrochloride

M. Wt	392.93
Formula	C₁₉H₂₈N₆O.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1245907-03-2
PubChem ID	46911725
InChi Key	DXVATYHPJJPMIN-UHFFFAOYSA-N
Smiles	CC1=CC(NC2=NNC(C)=C2)=NC(NC(C)CCCC(C)(C)O)=C1C#N.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC-A 2317 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.29	100
	ethanol	19.65	50

Preparing Stock Solutions for TC-A 2317 hydrochloride

The following data is based on the product molecular weight 392.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.72 mL	25.45 mL
5 mM	0.51 mL	2.54 mL	5.09 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for TC-A 2317 hydrochloride

References are publications that support the biological activity of the product.

Ando 3-Cyano-6-(-5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors. Bioorg.Med.Chem.Lett. 2010 PMID: 20573509