TBB
Tocris Bioscience, part of Bio-Techne | Catalog # 2275
Selective cell-permeable CK2 inhibitor
Key Product Details
Description
Selective cell-permeable CK2 inhibitor
Alternative Names
NSC 231634
Product Description
TBB is a cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.Product Specifications
Molecular Weight
434.71
Formula
C6HBr4N3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4,5,6,7-Tetrabromobenzotriazole
CAS Number
17374-26-4
PubChem ID
1694
InChI Key
OMZYUVOATZSGJY-UHFFFAOYSA-N
SMILES
BrC1=C2NN=NC2=C(Br)C(Br)=C1Br
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.47 | 100 |
Preparing Stock Solutions
for TBB
The following data is based on the product molecular weight 434.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.30 mL | 11.50 mL | 23.00 mL |
| 5 mM | 0.46 mL | 2.30 mL | 4.60 mL |
| 10 mM | 0.23 mL | 1.15 mL | 2.30 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pagano Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J.Med.Chem. 2004 PMID: 15566294
- Zien Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2. Biochim.Biophys.Acta. 2005 PMID: 16203192
- Sarno Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'). FEBS Lett. 2001 PMID: 11343704
Product Specific Notices for TBB
For research use only
Loading...
Loading...