TAT-PDHPS1

Name: TAT-PDHPS1
Brand: Tocris Bioscience
SKU: 7832

Tocris Bioscience, part of Bio-Techne | Catalog # 7832

Citations (2)

COA / SDS

YAP inhibitor

Key Product Details

Description:	YAP inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	3744.32

View Full Technical Details for TAT-PDHPS1

Technical Data
Citations

Biological Activity for TAT-PDHPS1

TAT-PDHPS1 is a YAP inhibitor (Yes-associated protein inhibitor). It comprises the endogenous peptide PDHPS1 and the cell-penetrating peptide sequence TAT. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), which activates protein phosphatase 2A (PP2A). This activation leads to the phosphorylation of YAP and the suppression of YAP-targeted genes. TAT-PDHPS1 inhibits the proliferation of ovarian cancer cells in vitro and ovarian tumor growth in a subcutaneous xenograft mouse model.

Technical Data for TAT-PDHPS1

M. Wt	3744.32
Formula	C₁₅₆H₂₈₀N₆₂O₄₅
Single Letter Sequence	GRKKRRQRRRPPQQIATTTASAATAAAIGATPRAK
Storage	Store at -20°C
Purity	≥95% (HPLC)
InChi Key	NNCYONQIMWXOHL-MRKNDOTPSA-N
Smiles	O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAT-PDHPS1

Solubility

Soluble to 2mg/ml in water

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References for TAT-PDHPS1

References are publications that support the biological activity of the product.

Pan Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling. Mol.Cancer Ther. 2022 PMID: 35545004