TAT-Gap19

Name: TAT-Gap19
Brand: Tocris Bioscience
SKU: 6227

Tocris Bioscience, part of Bio-Techne | Catalog # 6227

Citations (11)

COA / SDS

Cx43 hemichannel blocker

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Cx43 hemichannel blocker

View all Gap Channel Blockers »

Product Description

TAT-Gap19 is a Cx43 hemichannel blocker (IC₅₀ ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 (Cat. No. 5353). Active in vivo. Brain penetrant.

Product Specifications

Molecular Weight

2703.28

Formula

C₁₁₉H₂₁₂N₄₆O₂₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1507930-54-2

PubChem ID

127021051

InChI Key

ALNCFPIRTLVJPY-XELKYWHDNA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Freitas-Andrade and Naus Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 2016 PMID: 25913636
Abudara The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 2014 PMID: 25374505