TASP 0433864

Name: TASP 0433864
Brand: Tocris Bioscience
SKU: 5362

Tocris Bioscience, part of Bio-Techne | Catalog # 5362

Citations (1)

COA / SDS

Selective positive allosteric modulator of mGlu2 receptors

Key Product Details

Description:	Selective positive allosteric modulator of mGlu₂ receptors
Chemical Name:	(2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	329.39

View Full Technical Details for TASP 0433864

Technical Data
Citations

Biological Activity for TASP 0433864

TASP 0433864 is a selective mGlu₂ receptor positive allosteric modulator (EC₅₀ values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT_2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.

Compound Libraries for TASP 0433864

TASP 0433864 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for TASP 0433864

M. Wt	329.39
Formula	C₁₈H₂₃N₃O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1431980-60-7
PubChem ID	124201847
InChi Key	IZYYTLCSQBACIP-AWEZNQCLSA-N
Smiles	CC(C)(C)C1=CC=C(OC[C@@H]2CN3C(O2)=NC(C(N)=O)=C3C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TASP 0433864

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.94	100
	ethanol	6.59	20

Preparing Stock Solutions for TASP 0433864

The following data is based on the product molecular weight 329.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.18 mL	30.36 mL
5 mM	0.61 mL	3.04 mL	6.07 mL
10 mM	0.30 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

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References for TASP 0433864

References are publications that support the biological activity of the product.

Hiyoshi Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. J.Pharmacol.Exp.Ther. 2014 PMID: 25277141