Tariquidar dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5757
Potent P-glycoprotein (P-gp) inhibitor
Key Product Details
Description
Potent P-glycoprotein (P-gp) inhibitor
Product Description
Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concentration. Potentiates the cytotoxic effects of doxorubicin (Cat. No. 2252) and mitoxantrone (Cat. No. 4250) in vitro.Product Specifications
Molecular Weight
719.66
Formula
C38H38N4O6.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[2-[[[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride
CAS Number
1992047-62-7
PubChem ID
121513890
InChI Key
ZJCJRGRTDKIFJJ-UHFFFAOYSA-N
SMILES
O=C(C1=CC(OC)=C(OC)C=C1NC(C2=CN=C(C=CC=C3)C3=C2)=O)NC(C=C4)=CC=C4CCN5CC6=CC(OC)=C(OC)C=C6CC5.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.98 | 50 |
Preparing Stock Solutions
for Tariquidar dihydrochloride
The following data is based on the product molecular weight 719.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.78 mL | 13.90 mL | 27.79 mL |
| 2.5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 25 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Loo Mapping the binding site of the inhibitor Tariquidar that stabilizes the first transmembrane domain of P-glycoprotein. J.Biol.Chem. 2015 PMID: 26507655
- Kannan The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem.Neurosci. 2011 PMID: 22778859
Product Specific Notices for Tariquidar dihydrochloride
For research use only
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