Takinib

Name: Takinib
Brand: Tocris Bioscience
SKU: 6430

Tocris Bioscience, part of Bio-Techne | Catalog # 6430

Citations (3)

COA / SDS

Potent and selective TAK1/MAP3K7 kinase inhibitor

Key Product Details

Description:	Potent and selective TAK1/MAP3K7 kinase inhibitor
Chemical Name:	N¹-(1-Propyl-1H-benzimidazol-2-yl)-1,3-benzenedicarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	322.37

View Full Technical Details for Takinib

Technical Data
Citations

Biological Activity for Takinib

Takinib is a potent and selective TAK1/MAP3K7 kinase inhibitor (IC₅₀ = 8.2-9.5 nM). Selective for TAK1 over IRAK4, IRAK1, GCK, CLK2 and MINK1 (IC₅₀ values = 120, 390, 430, 430 and 1900 nM, respectively). Demonstrates weak inhibition at Src and Yes1. Exhibits no inhibition of MAP2K or other MAP3K family members. Induces apoptosis following TNF-α stimulation in in vitro models of rheumatoid arthritis and metastatic breast cancer.

Compound Libraries for Takinib

Takinib is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Takinib

M. Wt	322.37
Formula	C₁₈H₁₈N₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1111556-37-6
PubChem ID	37750349
InChi Key	UOZVVPXKJGOFIG-UHFFFAOYSA-N
Smiles	CCCN1C(NC(C2=CC(C(N)=O)=CC=C2)=O)=NC3=CC=CC=C13

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Takinib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	32.24	100

Preparing Stock Solutions for Takinib

The following data is based on the product molecular weight 322.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.10 mL	15.51 mL	31.02 mL
5 mM	0.62 mL	3.10 mL	6.20 mL
10 mM	0.31 mL	1.55 mL	3.10 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for Takinib

References are publications that support the biological activity of the product.

Totzke Takinib, a selective TAK1 inhibitor, broadens the therapeutic efficacy of TNF-α inhibition for cancer and autoimmune disease. Cell Chem.Biol. 2017 PMID: 28820959