TAK 715
Tocris Bioscience, part of Bio-Techne | Catalog # 4254
Potent p38 MAPK inhibitor; anti-inflammatory
Key Product Details
Description
Potent p38 MAPK inhibitor; anti-inflammatory
Product Description
TAK 715 is an inhibitor of p38 MAPK (IC50 = 7.1 nM for p38 MAPKα). Also inhibits Wnt-3a-stimulated β-catenin signaling. Inhibits 22 kinases by more than 80%, including CK1δ/ε. Anti-inflammatory and anti-rheumatoid arthritis agent. Orally bioavailable.Product Specifications
Molecular Weight
399.51
Formula
C24H21N3OS
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[2-Ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]benzamide
CAS Number
303162-79-0
PubChem ID
90488922
InChI Key
BRYAJHADJWBFQY-UHFFFAOYSA-N
SMILES
CCC1=NC(C3=CC(C)=CC=C3)=C(C2=C(NC(C4=CC=CC=C4)=O)N=CC=C2)S1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.95 | 100 | |
| Ethanol | 19.98 | 50 |
Preparing Stock Solutions
for TAK 715
The following data is based on the product molecular weight 399.51
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.50 mL | 12.52 mL | 25.03 mL |
| 5 mM | 0.50 mL | 2.50 mL | 5.01 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.50 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Verkaar Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ε. Chem.Biol. 2011 PMID: 21513885
- Miwatashi Novel inhibitor of p38 MAP kinase as an anti-TNF-α drug: discovery of N-[4-{2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent. J.Med.Chem. 2005 PMID: 16162000
Product Specific Notices for TAK 715
For research use only
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