T3 CLK
Tocris Bioscience, part of Bio-Techne | Catalog # 7570
Potent and selective pan-CLK inhibitor; also inhibits DYRK1A/B
Key Product Details
Description
Potent and selective pan-CLK inhibitor; also inhibits DYRK1A/B
Product Description
T3 CLK is a potent and selective pan CDC-like kinase (CLK) inhibitor (IC50 values are 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively). T3 CLK also inhibits DYRK1A/B (IC50 values are 230 nM and 260 nM for DYRK1B and DYRK1A, respectively in cellular assays). Exhibits dose-dependent alternative splicing effects in HCT116 colorectal cancer cells. T3 CLK is cell permeable, stable and non-toxic.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the T3 CLK probe summary on the SGC website.Product Specifications
Molecular Weight
482.58
Formula
C28H30N6O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide
CAS Number
2109805-56-1
PubChem ID
132585205
InChI Key
IEFFSHLHNYVSEF-UHFFFAOYSA-N
SMILES
O=C(NC=1N=C2C=CC(=CN2C1)C=3C=CN=CC3)C4=CC=C(C=C4)C(C(=O)N5CCN(C)CC5)(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.13 | 50 with gentle warming | |
| Ethanol | 4.83 | 10 with gentle warming |
Preparing Stock Solutions
for T3 CLK
The following data is based on the product molecular weight 482.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.14 mL | 20.72 mL | 41.44 mL |
| 2.5 mM | 0.83 mL | 4.14 mL | 8.29 mL |
| 5 mM | 0.41 mL | 2.07 mL | 4.14 mL |
| 25 mM | 0.08 mL | 0.41 mL | 0.83 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Funnell CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor. Nat.Commun. 2017 PMID: 28232751
Product Specific Notices for T3 CLK
For research use only
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