t-TUCB
Tocris Bioscience, part of Bio-Techne | Catalog # 6757
Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive
Key Product Details
Description
Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive
Product Description
t-TUCB is a potent soluble epoxide hydrolase (sEH) Inhibitor (IC50 = 0.9 nM). Enhances hepatic eNOS phosphorylation and NO release. Exhibits antihypertensive and cardioprotective actions in cirrhotic rat models. Suppress the activation of HSCs and reduce hepatic fibrosis through inhibition of NF-κB/IκBα signaling. Anti-inflammatory and antinociceptive.Product Specifications
Molecular Weight
438.40
Formula
C21H21F3N2O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[[trans-4-[[[[4-(Trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]benzoic acid
CAS Number
948304-40-3
PubChem ID
16756850
InChI Key
XDVFKCZZXOGEMN-UHFFFAOYSA-N
SMILES
OC(C1=CC=C(C=C1)O[C@H]2CC[C@H](NC(NC3=CC=C(C=C3)OC(F)(F)F)=O)CC2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.84 | 100 |
Preparing Stock Solutions
for t-TUCB
The following data is based on the product molecular weight 438.40
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.41 mL | 22.81 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Deng Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis. Prostaglandins Other Lipid Mediat. 2017 PMID: 28822809
- Hwang Orally bioavailable potent soluble epoxide hydrolase inhibitors. J.Med.Chem. 2007 PMID: 17616115
Product Specific Notices for t-TUCB
For research use only
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