T 5601640

Name: T 5601640
Brand: Tocris Bioscience
SKU: 5269

Tocris Bioscience, part of Bio-Techne | Catalog # 5269

COA / SDS

Selective LIMK2 inhibitor; antitumor

Discontinued Product

5269 has been discontinued. View all LIMK Inhibitors products.

Key Product Details

Description:	Selective LIMK2 inhibitor; antitumor
Alternative Names:	T56-LIMKi
Chemical Name:	3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	389.33

View Full Technical Details for T 5601640

Technical Data
Citations

Biological Activity for T 5601640

T 5601640 is a selective LIM kinase 2 (LIMK2) inhibitor; inhibits cofilin phosphorylation in cells that overexpress LIMK2 but not LIMK1. Attenuates the growth of several cancer cell lines. Reduces phospho-cofilin levels and Panc-1 tumor size in a mouse xenograft model.

Compound Libraries for T 5601640

T 5601640 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for T 5601640

M. Wt	389.33
Formula	C₁₉H₁₄F₃N₃O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	924473-59-6
PubChem ID	9438169
InChi Key	XVOKFRPKSAWELK-UHFFFAOYSA-N
Smiles	O=C(C2=CC=CC(NC(C3=CC(C)=NO3)=O)=C2)NC1=CC(C(F)(F)F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for T 5601640

References are publications that support the biological activity of the product.

Mashiach-Farkash Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget 2012 PMID: 22776759
Rak Novel LIMK2 inhibitor blocks Panc-1 tumor growth in a mouse xenograft model. Oncoscience 2014 PMID: 25593987