SU 3327
Tocris Bioscience, part of Bio-Techne | Catalog # 3607
Selective JNK inhibitor
Key Product Details
Description
Selective JNK inhibitor
Alternative Names
Halicin
Product Description
SU 3327 is a selective inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 0.7 μM). Inhibits the protein-protein interaction between JNK and JIP (IC50 = 239 nM). Displays selectivity over p38 MAPK and Akt. Restores insulin sensitivity in a mouse model of type-2 diabetes. Displays antibiotic activity against a range of bacteria including S.aureus, A.baumanni, C.difficile and M.tuberculosis.Product Specifications
Molecular Weight
261.30
Formula
C5H3N5O2S3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
5-[(5-Nitro-2-thiazolyl)thio]-1,3,4thiadiazol-2-amine
CAS Number
40045-50-9
PubChem ID
11837140
InChI Key
NQQBNZBOOHHVQP-UHFFFAOYSA-N
SMILES
NC2=NN=C(S2)SC1=NC=C([N+]([O-])=O)S1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.13 | 100 | |
| Ethanol | 2.61 | 10 |
Preparing Stock Solutions
for SU 3327
The following data is based on the product molecular weight 261.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.83 mL | 19.14 mL | 38.27 mL |
| 5 mM | 0.77 mL | 3.83 mL | 7.65 mL |
| 10 mM | 0.38 mL | 1.91 mL | 3.83 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Higashihira Halicin is effective against staphylococcus aureus biofilms in vitro. Clin.Orthop.Relat.Res. 2022 PMID: 35583504
- De Design, synthesis and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun N-terminal kinase. J.Med.Chem. 2009 PMID: 19271755
Product Specific Notices for SU 3327
For research use only
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