Stressin I

Name: Stressin I
Brand: Tocris Bioscience
SKU: 1608
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1608

Citations (19)

COA / SDS

CRF1 agonist

Key Product Details

Description:	CRF₁ agonist
Alternative Names:	cyclo(31-34)[D-Phe¹²,Nle^21,38,Glu³¹,Lys³⁴]Ac-hCRF (4-41)
Purity:	≥95% (HPLC)
Molecular Weight:	4472.24

View Full Technical Details for Stressin I

Technical Data
Citations

Biological Activity for Stressin I

Stressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF₁) agonist (K_i values are 1.5 and 224 nM for CRF₁ and CRF₂ receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data for Stressin I

M. Wt	4472.24
Formula	C₂₀₃H₃₃₇N₅₇O₅₆
Single Letter Sequence	PPISLDLTFHLLREVLEXARAEQLAQQEHSKRKLXEII (Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	935739-46-1
PubChem ID	90479815
InChi Key	HZKFMBAUDWRPRY-WNBAZHKDSA-N
Smiles	CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(C)=O)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Stressin I

Solubility

Soluble to 1mg/ml in water

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References for Stressin I

References are publications that support the biological activity of the product.

Rivier Receptor-selective cortico. releasing factor analogs. Endocrin.Soc.Abstr.
Bruchas CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. PLoS One. 2009 PMID: 20052275
Rivier Stressin₁-A, a potent cortico. releasing factor receptor 1 (CRF₁)-selective peptide agonist. J.Med.Chem. 2007 PMID: 17335188