Stattic
Tocris Bioscience, part of Bio-Techne | Catalog # 2798
Selective STAT3 inhibitor
Product Description
Stattic is a small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.Product Specifications
Molecular Weight
211.19
Formula
C8H5NO4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
6-Nitrobenzo[b]thiophene 1,1-dioxide
CAS Number
19983-44-9
PubChem ID
2779853
InChI Key
ZRRGOUHITGRLBA-UHFFFAOYSA-N
SMILES
O=S2(C1=CC([N+]([O-])=O)=CC=C1C=C2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.56 | 50 |
Preparing Stock Solutions
for Stattic
The following data is based on the product molecular weight 211.19
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 9.47 mL | 47.35 mL | 94.70 mL |
| 2.5 mM | 1.89 mL | 9.47 mL | 18.94 mL |
| 5 mM | 0.95 mL | 4.74 mL | 9.47 mL |
| 25 mM | 0.19 mL | 0.95 mL | 1.89 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schust Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 2006 PMID: 17114005
Product Specific Notices for Stattic
For research use only
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