SRPIN340

Name: SRPIN340
Brand: Tocris Bioscience
SKU: 5063

Tocris Bioscience, part of Bio-Techne | Catalog # 5063

Citations (2)

COA / SDS

Selective SRPK1 inhibitor

Discontinued Product

5063 has been discontinued. View all Other Kinase Inhibitors products.

Key Product Details

Description:	Selective SRPK1 inhibitor
Chemical Name:	N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	349.35

View Full Technical Details for SRPIN340

Technical Data
Citations

Biological Activity for SRPIN340

SRPIN340 is a selective serine arginine protein kinase (SRPK) 1 inhibitor (K_i = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Down-regulates expression of VEGF₁₆₅ but does not affect VEGF_165b expression.

Technical Data for SRPIN340

M. Wt	349.35
Formula	C₁₈H₁₈F₃N₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	218156-96-8
PubChem ID	2797577
InChi Key	DWFGGOFPIISJIT-UHFFFAOYSA-N
Smiles	O=C(C3=CC=NC=C3)NC1=C(N2CCCCC2)C=CC(C(F)(F)F)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for SRPIN340

References are publications that support the biological activity of the product.

Fukuhara Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc.Natl.Acad.Sci.USA 2006 PMID: 16840555
Oltean SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochem.Soc.Trans. 2012 PMID: 22817743
Gammons SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest.Ophthalmol.Vis.Sci. 2013 PMID: 23761094

SRPIN340

Tocris Bioscience, part of Bio-Techne | Catalog # 5063

Key Product Details

Biological Activity for SRPIN340

Technical Data for SRPIN340

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for SRPIN340

Product Documents for SRPIN340

COA

Certificate of Analysis

SDS

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