SR 58611A hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3986
β3 agonist; displays anxiolytic and antidepressant effects
Key Product Details
Description
β3 agonist; displays anxiolytic and antidepressant effects
Product Description
SR 58611A hydrochloride is a selective β3-adrenergic receptor agonist. Displays both anxiolytic and antidepressant effects in rodent models. Orally active and brain penetrant.Product Specifications
Molecular Weight
440.36
Formula
C22H26ClNO4.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
[[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yacetic acid ethyl ester hydrochloride
CAS Number
121524-09-2
PubChem ID
121888
InChI Key
NQIZCDQCNYCVAS-RQBPZYBGSA-N
SMILES
O=C(OCC)COC1=CC=C(CC[C@H](NC[C@H](O)C3=CC(Cl)=CC=C3)C2)C2=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.04 | 100 |
Preparing Stock Solutions
for SR 58611A hydrochloride
The following data is based on the product molecular weight 440.36
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.35 mL | 22.71 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Tamburella The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes. Eur.Neuropsychopharmacol. 2010 PMID: 20537869
- Claustre Effects of the β3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile. Neuroscience 2008 PMID: 18691638
- Stemmelin Stimulation of the β3-adrenoceptor as a novel treatment strategy for anxiety and depressive disorders. Neuropsychopharmacology 2008 PMID: 17460614
- Consoli Behavioral effects of the β3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs? Eur.J.Pharmacol 2007 PMID: 17669397
Product Specific Notices for SR 58611A hydrochloride
For research use only
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