SR 27897
Tocris Bioscience, part of Bio-Techne | Catalog # 2190
Potent and selective CCK1 antagonist
Key Product Details
Description
Potent and selective CCK1 antagonist
Alternative Names
Lintitript
Product Description
SR 27897 is a potent, non-peptide CCK1 receptor antagonist that displays > 33-fold selectivity over CCK2 receptors (EC50 values are 6 and 200 nM respectively). Causes an increase in plasma leptin levels and increases food intake in rats in vivo.Product Specifications
Molecular Weight
411.86
Formula
C20H14ClN3O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-[[[4-(2-Chlorophenyl)-2-thiazolyl]amino]carbonyl]-1H-indole-1-acetic acid
CAS Number
136381-85-6
PubChem ID
122077
InChI Key
ILNRQFBVVQUOLP-UHFFFAOYSA-N
SMILES
OC(=O)CN1C(=CC2=CC=CC=C12)C(=O)NC1=NC(=CS1)C1=CC=CC=C1Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.59 | 50 |
Preparing Stock Solutions
for SR 27897
The following data is based on the product molecular weight 411.86
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.86 mL | 24.28 mL | 48.56 mL |
| 2.5 mM | 0.97 mL | 4.86 mL | 9.71 mL |
| 5 mM | 0.49 mL | 2.43 mL | 4.86 mL |
| 25 mM | 0.10 mL | 0.49 mL | 0.97 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cano Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors. Br.J.Pharmacol. 2003 PMID: 14534148
- Gully Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors. Eur.J.Pharmacol.
- Gouldson Contrasting roles of Leu356 in the human CCK1 receptor for antagonist SR 27897 and agonist SR 146131 binding. Eur.J.Pharmacol. 1999 PMID: 10594328
Product Specific Notices for SR 27897
For research use only
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