SR 11237

Name: SR 11237
Brand: Tocris Bioscience
SKU: 3411

Tocris Bioscience, part of Bio-Techne | Catalog # 3411

Citations (33)

COA / SDS

Pan RXR agonist

Key Product Details

Description:	Pan RXR agonist
Alternative Names:	BMS 649
Chemical Name:	4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	380.48

View Full Technical Details for SR 11237

Technical Data
Citations

Biological Activity for SR 11237

SR 11237 is a pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity.

Compound Libraries for SR 11237

SR 11237 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SR 11237

M. Wt	380.48
Formula	C₂₄H₂₈O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	146670-40-8
PubChem ID	127019
InChi Key	ZZUKALQMHNSWTK-UHFFFAOYSA-N
Smiles	CC1(C)C2=C(C=CC(C4(OCCO4)C3=CC=C(C(O)=O)C=C3)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SR 11237

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.05	100

Preparing Stock Solutions for SR 11237

The following data is based on the product molecular weight 380.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.63 mL	13.14 mL	26.28 mL
5 mM	0.53 mL	2.63 mL	5.26 mL
10 mM	0.26 mL	1.31 mL	2.63 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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Reconstitution Calculator

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References for SR 11237

References are publications that support the biological activity of the product.

Benoit RAR-independent RXR signaling induces t(15;17) leukemia cell maturation. EMBO J. 1999 PMID: 10601023
Zhou Retinoid X receptor agonists inhibit phorbol-12-myristate-13-acetate (PMA)-induced differentiation of monocytic THP-1 cells into macrophages. Mol.Cell.Biochem. 2010 PMID: 19784811
Chiba Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells. Mol.Cell.Biol. 1997 PMID: 9154799