SR 1078
Tocris Bioscience, part of Bio-Techne | Catalog # 4874
RORα/γ agonist
Product Description
SR 1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.Licensing Information
Sold under license from The Scripps Research Institute.Product Specifications
Molecular Weight
431.25
Formula
C17H10F9NO2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide
CAS Number
1246525-60-9
PubChem ID
17980288
InChI Key
DUXWIYXHHGNUJU-UHFFFAOYSA-N
SMILES
OC(C(F)(F)F)(C(F)(F)F)C(C=C1)=CC=C1NC(C2=CC=C(C(F)(F)F)C=C2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.12 | 100 | |
| Ethanol | 43.12 | 100 |
Preparing Stock Solutions
for SR 1078
The following data is based on the product molecular weight 431.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.32 mL | 11.59 mL | 23.19 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.32 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wang Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 2012 PMID: 22509368
- Wang Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chem.Biol. 2010 PMID: 20735016
Product Specific Notices for SR 1078
For research use only
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